The zerginvasion of Aiur devastated the planet and Antioch was no exception, experiencing numerous zerg attacks. Two days after the invasion's conclusion proper (the manifestation of the Overmind), the outpost, under the command of PraetorFenix, was on the edge of the abyss in terms of manpower and resources. As such, the Conclave ordered that Antioch be reinforced, as the first priority of the protoss forces was to strengthen their defenses.
Reinforcements under the leadership of ExecutorArtanis arrived at Antioch, having successfully engaged numerous zerg patrols in the lands surrounding it. Fortifying the base, the protoss then launched a successful counterattack against the zerg Tiamat Brood forces which occupied the ridge to the north.
While the main protoss strike force carried out an attack on the zerg-held province of Scion, Antioch fell under attack by overwhelming zerg forces. The defense was not nearly as successful as the first battle, and Fenix was mortally wounded.
By the end of the war, Antioch had been reduced to a wasteland.
The area was colonized by the Shel'na Kryhas, protoss refugees stranded after the evacuation of Aiur. They settled the area, eliminating the flying zerg in the area around Antioch, though fighting running battles with the large number of ground zerg in the region. In 2503, the group was largely wiped out.
Its legacy could be said to have lived on in the base of New Antioch on Shakuras, though the city was destroyed with the planet.
↑Fenix: "Alas, all of our Probes were lost in the last Zerg attack, and we had no resources with which to replace them." StarCraft. Vivendi Games. Level/area: First Strike (in English). 1998.
↑Aldaris: "The Conclave has dictated that our first priority is to strengthen our defenses. You must reinforce our outpost in Antioch and make certain that the province does not fall to the Zerg." StarCraft. Vivendi Games. Level/area: First Strike (in English). 1998